(Fig 1d) The effect of applied vacuum on blood flow rate
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We found that applying vacuum to the area surrounding the microneedle puncture sites encourages localized blood flow, stretches the puncture sites open, and leads to substantially increased blood flow rates. To optimize the level of vacuum used for blood collection, we tested devices with -5, -12, and -20 inHg of vacuum, using a vacuum reservoir connected to each device.
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2018-02-19



