METTL3-METTL14 heterodimer bound to the SAM competitive small molecule inhibitor STM3006
收藏Protein Data Bank Japan2026-03-04 更新2026-04-19 收录
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METTL3-METTL14 heterodimer bound to the SAM competitive small molecule inhibitor STM3006 Descriptor: 2-[[4-(6-bromanyl-2~{H}-indazol-4-yl)-1,2,3-triazol-1-yl]methyl]-6-[(4,4-dimethylpiperidin-1-yl)methyl]imidazo[1,2-a]pyridine, N6-adenosine-methyltransferase catalytic subunit, N6-adenosine-methyltransferase non-catalytic subunit Authors: Pilka, E.S, Thomas, B, Blackaby, W, Hardick, D, Feeney, K, Ridgill, M, Rotty, B, Rausch, O. Deposit date: 2022-11-13 Release date: 2023-09-20 Last modified: 2026-03-04 Method: X-RAY DIFFRACTION (2.213 Å) Cite: Inhibition of METTL3 Results in a Cell-Intrinsic Interferon Response That Enhances Antitumor Immunity. Cancer Discov, 13, 2023
创建时间：
2022-11-13
