3D microelectrode cluster and stimulation paradigm yield powerful analgesia without noticeable adverse effects

The dataset contains the underlying data for the figures in the paper
"3D microelectrode cluster and stimulation paradigm yield powerful
analgesia without noticeable adverse effects" by M. Forni et al.,
Science Advances, 2021. In the reported study, we present a newly
developed biocompatible gelatin-embedded cluster of microelectrodes that
enable higly customizable stimulation in the periaqueductal gray/dorsal
raphe nucleus in awake rats. We were able to select a subset of electrodes
for each individual, that upon stimulation provided significant pain
inhibition during both normal and hyperalgesia conditions, without
noticable side effects. Pain responses were quantified in terms of evoked
field potentials (FP) and neuronal activity (z score), as well as
withdrawal rate (WR) resulting from stimulating the skin with either a
CO2-laser or a tactile stimulator, and analyzed with respect to multiple
variables, such as time from stimulation onset, effect in comparison to
morphine administration etc. Also, the effects of stimulation were
quantified in terms of gait parameters (speed and paw-usage symmetry). The
location of implanted electrodes was verified using computed tomography
(CT) imaging and superimposition to the Waxholm brain atlas. The dataset
contains the CT images for each anaimal, as obtained after alignment to
the atlas.