Association between birth defects by organ system and ARV drug exposures (French Perinatal Cohort [ANRS CO1/CO11]).

All organ system defects significantly associated with ART in multivariate main analysis with either EUROCAT or MACDP classification are presented in this table. AORs obtained by multivariate logistic regression adjusted systematically for maternal age, geographical origin, IDU, and type of maternity center (ranged from 1 to 3 according to the presence of a pediatrician on site, a neonatology unit, or a neonatal intensive care unit), and for all other drugs associated in univariate analysis with p0.10 to the organ system considered in either classification (central nervous system defects adjusted for didanosine; heart defects adjusted for indinavir, emtricitabine, lamivudine, and zalcitabine; head and neck defects adjusted for zidovudine, zalcitabine, lamivudine, emtricitabine and efavirenz). Univariate analysis showing the association between birth defects by organ system and all drugs evaluated is presented in Table 3. p-Values are global p-value for the three categories in each type of exposure.aNumber of birth defects/total in exposure category.BD, birth defect; DDI, didanosine; EFV, efavirenz; IND, indinavir; LB, live birth; NA, not applicable/no child in this category; SB, stillbirth; T, trimester; ZDV, zidovudine.