Crystal Structure of human exonuclease 1 (Exo1) with DNA and compound ART5537

Crystal Structure of human exonuclease 1 (Exo1) with DNA and compound ART5537 Descriptor: 1-(4-chloranyl-2,7-naphthyridin-1-yl)-5-oxidanyl-3-[(1~{S})-1-phenylethyl]-2~{H}-pyrido[2,1-f][1,2,4]triazine-4,6-dione, DNA (5'-D(*CP*(GS)P*CP*TP*AP*GP*TP*CP*GP*TP*CP*AP*(TS))-3'), DNA (5'-D(P*AP*(SC)P*GP*AP*CP*TP*AP*GP*CP*(GS))-3'), ... Authors: Toste Rego, A, Pica, A, Cornaciu, I, Burgdorf, L, Mann, S.E. Deposit date: 2025-09-08 Release date: 2025-12-17 Last modified: 2026-01-07 Method: X-RAY DIFFRACTION (2.199 Å) Cite: Discovery of ART5537: A Potent and Selective Small-Molecule Probe for EXO1. J.Med.Chem., 68, 2025