Neurons undergo IFN?-driven persistent epigenetic shifts and synaptic remodeling in the inflamed brain [RNA-Seq]

Our study provides novel evidence that neuronal intrinsic epigenetic changes are established as a consequence of cytotoxic T cell-mediated immune attacks and persist long after the resolution of the inflammatory process and associate to long lasting synaptic loss Overall design: Single nuclear transcriptomes of sorted nuclei derived from Brain hippocampal resections of Rasmussen encephalitis patients