Keratinocyte-derived circulating exosomal miRNAs as a novel biomarker of disease severity in psoriasis

To reveal the relationship between circulating exosomal miRNAs and the disease severity of psoriasis, we performed next-generation sequencing from plasma exosomes of patients with high psoriasis area and severity index (PASI) score (>10) and low PASI score (<5). We identified 19 differentially expressed exosomal miRNAs that were significantly different between the groups. We validated the top three up-and down-regulated exosomal miRNAs using quantitative real-time PCR. We performed next-generation sequencing from plasma exosomes of patients with high psoriasis area and severity index (PASI) score (>10) and low PASI score (<5) Please note that the processed data columns are assocaited with the samples as below: X2_OYJ Mild 1 X2_NYH Mild 2 X2_KJH Mild 3 X1_KSJ Severe 1 X1_KST Severe 2 X1_YJM Severe 3 X1_JBM Severe 4 X1_JKS Severe 5