Transcriptom analysis of ZFP708 loss and overexpression in preimplantation embryos and embryonic stem cells. Transcriptom analysis of ZFP708 loss and overexpression in preimplantation embryos and embryonic stem cells

This work describes the function and targets of a maternal KRAB-Zinc finger protein, ZFP708, which specifically mediates maintenance of DNA-methylation at a subset of LTR retrotransposons during embryonic epigenetic reprogramming. Overall design: This dataset contains RNA-seq analysis of wildtype and maternal ZFP708 knock out GV oocytes, zygotes, 2-cell stage embryos, blastocysts and embryonic stem cells derived from maternal/zygotic ZFP708 embryos. It further contains expression analysis of ZFP708 overexpressing mouse embryonic stem cells.