TPNO/KPNB1 (transportin/importin beta) sequester the Nup107-160 complex

After disassembly of the NPC in prophase, the Nup107-160 complex is sequestered through interaction with transportin (TPNO1) and/or importin-beta (KPNB1), as suggested by studies with Xenopus egg extracts and recombinant human proteins (Lau et al. 2009, Bernis et al. 2014), and in cultured human cells. Binding to TPNO1 and/or KPNB1 prevents Nup107-160 association with chromatin prior to the onset of NE reassembly.

在NPC（核孔复合体）解聚的早期阶段，Nup107-160复合体通过与运输蛋白（TPNO1）和/或输入蛋白-β（KPNB1）相互作用而被隔离，如Xenopus卵提取物和重组人蛋白的研究（Lau等人，2009年，Bernis等人，2014年）以及培养的人细胞中的研究所示。与TPNO1和/或KPNB1的结合阻止了Nup107-160在NE（核仁）重组开始之前与染色质的结合。