Homo sapiens Transcriptome or Gene expression. Homo sapiens

To investigate RNA editing in hepatocellular carcinoma (HCC), we deeply sequenced 18 RNA samples from 9 HCC patients to identify RNA editing events. In our sample cohort, we find 26,982 ± 12,574 (Mean ± SD) editing sites with 89.51% ± 2.71% (Mean ± SD) canonical A->G edits in each sample. Comparing the difference between normal and tumor samples of each patient, we find 7 non-synonymous specific editing events including 4 tumor-specific edits and 3 normal-specific edits in CDS region, as well as 292 edits showing variance in editing degree. Meanwhile, the significant expression changes of 150 genes being associated with RNA editing are found in tumor, including 3 of 4 most significant genes are cancer or disease related. All these findings indicate that the RNA editing modification may play a role in the development of hepatocellular carcinoma.