Highly Enantioselective Amination of α-Substituted α-Cyanoacetates with Chiral Catalysts Accessible from Both Quinine and Quinidine

The catalytic construction of nitrogen-substituted quaternary stereocenters is an important and challenging task in asymmetric synthesis. In
this paper, we describe the use of 6‘-OH-modified cinchona alkaloids that are accessible from either quinine or quinidine for the development
of a highly enantioselective amination of α,α-disubstituted carbonyl compounds that is suitable for the creation of nitrogen-substituted quaternary
stereocenters in either the R or S configuration.