Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 -- Crystal structure of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 in complex with Z1262628644 (DNV2_NS5A-x0472)

Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 -- Crystal structure of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 in complex with Z1262628644 (DNV2_NS5A-x0472) Descriptor: 2-(1H-pyrrol-1-yl)pyridin-3-amine, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, ... Authors: Aschenbrenner, J.C, Saini, M, Chopra, A, Marples, P.G, Balcomb, B.H, Lithgo, R.M, Fearon, D, von Delft, F, Ruiz, F.X, Arnold, E. Deposit date: 2025-03-06 Release date: 2025-04-02 Last modified: 2026-06-24 Method: X-RAY DIFFRACTION (1.74 Å) Cite: Crystallographic Fragment Screening of the Dengue Virus Polymerase Reveals Multiple Binding Sites for the Development of Non-nucleoside Antiflavivirals. J.Med.Chem., 68, 2025