Proline-Catalyzed Sequential syn-Mannich and [4 + 1]-Annulation Cascade Reactions To Form Densely Functionalized Pyrrolidines
收藏Figshare2016-02-15 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Proline_Catalyzed_Sequential_i_syn_i_Mannich_and_4_1_Annulation_Cascade_Reactions_To_Form_Densely_Functionalized_Pyrrolidines/2208643
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资源简介：
A highly efficient one-pot [4 + 1]-annulation process for the asymmetric synthesis of densely functionalized pyrrolidine derivatives is described. The in situ generated syn-Mannich adduct obtained via proline catalysis acts as a four-atom component, and Corey’s sulfur ylide or ethyl bromoacetate acts as a one-atom carbon source to construct pyrrolidine units in a highly enantio- and diastereoselective manner.
创建时间：
2016-02-15
