ALK in complex with alectinib with in-silico mutated residues

PyMol session file (.pse) files of the structure of ALK in complex from alectinib (original PDB accession 3AOX) with in-silico mutated residues as reported in figure 4. Computational mutagenesis was applied to residues known to confer resistance to TKIs in order to highlight their potential impact on drug binding and efficacy. The mutated residues are represented simultaneously for illustrative purposes.