C.difficile toxins trigger BMDC IL-1β release by activating an ASC-containing inflammasome.
收藏Figshare2016-02-24 更新2026-04-29 收录
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https://figshare.com/articles/dataset/_C_difficile_toxins_trigger_BMDC_IL_1_release_by_activating_an_ASC_containing_inflammasome_/759428
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BMDCs from WT C57BL/6 (genetically Nlrp1 deficient) mice and mice deficient in Nlrp3 and ASC were infected with C. difficile strains at an MOI of 10. Pro- and active caspase-1 (45 & 10 kDa, respectively) and pro- and mature IL-1β (31 & 17 kDa, respectively) release 8h post-infection was quantified by western blotting. 5 mM ATP served as a positive control (A). Quantification of IL-1β secretion in infected WT, Nlrp3 and ASC KO BMDC 8h post-infection. Data is represented as mean ± SEM, n = 4. ***p∧p∧∧∧/’p−/− difference from ASC−/−. P values were obtained using ANOVA with Bonferroni post-test analysis (B & C).
创建时间：
2016-02-24
