CaMK2D is a critical regulator of coactivation of leukemia stem cell factors in acute myeloid leukemia.

Relapse is one of the biggest challenges in treating acute myeloid leukemia (AML) due to leukemia stem cells (LSCs) resisting chemotherapy, providing a cellular reservoir to form the basis for relapse. Here, we identify CaMK2D is a critical regulator of stemness and leukemogenesis of AML. Transcriptionally, loss of CaMK2D was associated with down-regulation kinds of metabolic pathway of AML. Overall design: mRNA profiles of molm13 cell line with control vector and CaMK2D-KO vector were generated by deep sequencing, using Illumina HiSeq 4000. In total, six samples were sequenced.