Convergence of gut phageomes but not bacteriomes after experimental transplantation - Bacteriome data

Gut bacteriome and phageome was studied using 16S rRNA amplicone sequencing and shotgun metagenome sequencing, respectively. The 16S rRNA are deposited in this repository. Our data demonstrate divergent gut phageomes and bacteriomes in wild and captive non-SPF mice. Experimentally induced bacteriome dysbiosis in a mouse model can be treated by transplanting healthy phageomes, but the effects of phageome transplants on healthy adult gut microbiota are still unknown. We show that experimental transplantation of phageomes from wild to captive mice did not cause major shifts in recipient phageomes. However, the convergence of recipient-to-donor phageomes confirmed that wild phages can integrate into recipient communities. The differences in the subset of integrated phages between the two recipient mouse strains illustrate the context-dependent effects of phage transplantation. The transplantation did not impact recipient gut bacteriomes.