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Supporting data for The Functional Roles of SCD1/FADS2 Lipid Desaturases in Modulating Lipid Metabolic Activities and Redox-driven Ferroptosis in Ascites-derived Ovarian Cancer Cells

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Figshare2021-08-10 更新2026-04-28 收录
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https://figshare.com/articles/dataset/Supporting_data_for_The_Functional_Roles_of_SCD1_FADS2_Lipid_Desaturases_in_Modulating_Lipid_Metabolic_Activities_and_Redox-driven_Ferroptosis_in_Ascites-derived_Ovarian_Cancer_Cells/15134379
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1. The desaturation abilities of SCD1/FADS2 are aberrantly augmented in ascites-derived ovarian cancer cells.2. SCD1/FADS2 causes the elevation of poly- and mono-unsaturated fatty acids (UFAs) and enhanced oncogenic properties of ovarian cancer cells.3. SCD1/FADS2 modulates GSH/GSSG ratio and GPX4, preventing induction of ferroptosis.4.Targeting suppression of SCD1/FADS2 synergistically enhances cisplatin-mediated cytotoxicity in ascites-derived ovarian cancer cells.
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2021-08-10
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