PrPSc distribution in the brain of hamsters infected with CWD.

The relative intensity of PrPSc deposition in the hamster brain infected with CWD was scored on a 0 to 3 scale with 0 = no immunoreactivity, 1 = mild immunoreactivity, 2 = moderate immunoreactivity, and 3 = intense immunoreactivity.1PrPSc distribution data in cervids was extrapolated from previously published reports and unpublished observations (D.M.S.) of terminal, CWD-infected captive mule deer and experimentally, orally-inoculated mule deer and white-tailed deer.2Hypothalamic nuclei that were evaluated include the arcuate, dorsomedial, supraoptic, paraventricular and subincertal nuclei.3Thalamic nuclei that were evaluated include the centrolateral, laterodorsal, lateral posterior, posterior, ventral posterolateral, posteromedial, ventromedial, paracentral, paraventricular, and mediodorsal nuclei.