C13 bacterial consortium is sensitive to C. jejuni infection which impacts host-derived miRNAs targeting bacterial and host genes

C. jejuni infection altered C13 bacterial composition and modified host extracellular vesicle (EV)-derived miRNA expression profile, associated with changes in microbial virulence gene expression. Host-derived miRNAs may be an important component of host-microbiome communication. Overall design: Three groups of Germ Free (GF) Il10-/- mice were used in this study: 1) mice colonized with a defined consortium of 13 bacterial isolates (C13) representing the four most prominent phyla in the mouse gut. 2) C13 plus Campylobacter jejuni (C. jejuni) 81-176 and 3) GF alone.