Simple GEE with personality traits.

BackgroundParkinson’s disease (PD) significantly reduces quality of life (QoL), particularly due to its complex interplay of motor and nonmotor symptoms. While personality traits influence QoL in chronic diseases, their longitudinal effects in people with PD (PwPD) remain underexplored. This study evaluates the longitudinal predictive influence of neuroticism, conscientiousness, and openness on QoL in PwPD over two waves of the Survey of Health, Aging, and Retirement in Europe (SHARE).MethodsThis study utilized longitudinal data from 100 PwPD participants in waves 7 and 8 of the Survey of Health, Aging, and Retirement in Europe (SHARE). QoL was assessed using the CASP-12 scale, while personality traits were measured with the Big Five Inventory (BFI-10). Linear regressions and generalized estimating equations (GEE) were used to examine cross-sectional and longitudinal associations between personality traits and QoL, controlling for sociodemographic, psychosocial, and health-related variables.ResultsNeuroticism was consistently associated with lower QoL across all analyses. Cross-sectional results showed neuroticism as the strongest predictor of QoL decline in wave 7 (beta = -0.33, p ConclusionsNeuroticism plays a pivotal role in predicting QoL decline in PwPD, highlighting its utility as a target for psychological interventions aimed at emotional regulation and resilience building. While depressive symptoms and mobility limitations also contribute, integrating personality assessments into care strategies may improve outcomes. These findings advocate for a multidimensional approach to managing PD that addresses both clinical and psychological factors.