Role of the Host Translational Machinery in Zika Virus Replication
收藏DataCite Commons2021-07-23 更新2025-04-16 收录
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https://datahub.hku.hk/articles/dataset/Role_of_the_Host_Translational_Machinery_in_Zika_Virus_Replication/14898720/1
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资源简介：
The pandemic of ZIKV during 2013-2016 had alarmed the global world because of its association of rising cases of microcephaly in newborn in Brazil. Similar to most other flavivirus, ZIKV genome encodes for a single open reding frame with multiple transmembrane domains that is cleaved into at least 3 structural and 7 non-structural proteins. To synthesize such a complex multi-pass protein, transmembrane domains have to be inserted correctly during de-novo synthesis. It is generally believed that flavivirus polyprotein is targeted to translocon for insertion by signal recognition particle (SRP) pathway, but direct evidences are incomplete.<br>
提供机构：
University of Hong Kong
创建时间：
2021-07-23
