Rise time and deactivation of nAChR responses examined at different temperatures.

†Data for deactivation are expressed as the time required for the response to decay to 50% of the response after termination of agonist application. This parameter could not be determined for wild-type α7 activated by ACh, due to the rapid rate of agonist-induced desensitization.
Data are means ± SEM. Significant differences to responses recorded at RT are indicated (* = P<0.05, ** = P<0.01, *** = P<0.001).