Meta-Analysis of Intrauterine hCG Perfusion Efficacy in Recurrent Implantation Failure Defined by ESHRE Recommendations

The meta-analysis followed PRISMA guidelines and involved an extensive literature search in multiple databases, including PubMed, EMBASE, Web of Science, and the Cochrane Central Register of Controlled Trials. Inclusion criteria were based on ESHRE recommendations, focusing on cases with at least three failed implantations with high-quality embryos. The study incorporated a rigorous selection process, excluding studies with methodological flaws, and employed statistical analysis using R software and the 'meta' package.