Transcriptome profiling from Wild Type and PLSCR1 transgenic mouse(PLSCR1-TG)retina with acute ocular hypertension (AOH) treatment reveals the potential mechanism involved in glaucoma

Glaucoma is a leading cause of irreversible blindness worldwide. In pathogenesis of glaucoma, the molecular mechanisms remain largely unknown. Phospholipid scramblase 1 (PLSCR1) is a key regulator promoting RGCs apoptosis and their clearance by microglia. As evidenced in RGCs of PLSCR1 transgenic mice model treated with acute ocular hypertension, transcriptome profiling from Wild Type and PLSCR1 transgenic mouse(PLSCR1-TG)retina with AOH treatment would reveal the potential mechanism involved in glaucoma. Overall design: RNA-seq profiles of retina from WT and PLSCR1-TG after AOH treatment after 5 days