Effects of redox modulation by inhibition of Thioredoxin reductase on radiosensitivity and gene expression

ChEBI2010-12-03 更新2026-07-21 收录

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肿瘤氧化还原调控

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Effects of redox modulation by inhibition of Thioredoxin reductase on radiosensitivity and gene expression

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2010-12-03

Inhibition of Both EGFR and IGF1R Sensitized Prostate Cancer Cells to Radiation by Synergistic Suppression of DNA Homologous Recombination Repair

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DNA损伤修复

Reduced sensitivity of prostate cancer (PC) cells to radiation therapy poses a significant challenge in the clinic. Activation of epidermal growth factor receptor (EGFR), type 1 insulin-like growth fa

NIAID Data Ecosystem40

The effects of PKI-402 on breast tumor models’ radiosensitivity via dual inhibition of PI3K/mTOR

癌症靶向治疗

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PI3K/Akt/mTOR pathway activation causes relapse and resistance after radiotherapy in breast cancer (BC). We aimed to radiosensitize BC cell lines to irradiation (IR) by PKI-402, a dual PI3K/mTOR inhib

NIAID Data Ecosystem20

PARP inhibitor radiosensitization enhances anti-PD-L1 immunotherapy through depression of chemokine translation in small cell lung cancer

非小细胞肺癌免疫治疗

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Immunotherapy (IO) is an effective therapeutic for various cancers however the benefits are modest for small cell lung cancer (SCLC). The poor response of SCLC to anti-PD-1/PD-L1 IO is due in part to

NIAID Data Ecosystem10

The effects of PKI-402 on breast tumor models’ radiosensitivity via dual inhibition of PI3K/mTOR

癌症靶向治疗

放射增敏机制

Figshare2023-06-30 更新20

YTHDF2 inhibition potentiates radiotherapy by reprogramming suppressive myeloid cells [scRNA-Seq]. YTHDF2 inhibition potentiates radiotherapy by reprogramming suppressive myeloid cells [scRNA-Seq]

肿瘤免疫治疗

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RNA N6-methyladenosine (m6A) modification is implicated in cancer progression. However, the impact of m6A on the antitumor effects of radiotherapy and the related mechanisms are unknown. Here we show

NIAID Data Ecosystem20

Effects of redox modulation by inhibition of Thioredoxin reductase on radiosensitivity and gene expression

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