The Spliceosome as Quantum Router: Operator Coupling Determines Splice Outcome

The Spliceosome as Quantum Router: a zero-parameter measurement framework showing that operator coupling determines splice outcome across 700,000+ cells and 500M+ reads from 10 public datasets (7+ countries). Key findings: Operator coupling axis: 20 conditions, zero crossings (GSE131907, 208K cells) Splice junction XOR shift: +7.4% identity from fetal to cancer (7M junctions) Fetal exploration: 99.98% unique chains vs 98.4% cancer convergence Meditation recouples operators: K_RM +40% at 3 months (GSE174083, PNAS 2021) Mg vs Li at GNRA: 1,297 kJ/mol difference (OpenMM, PDB 1ZIF) Includes: 13 STAFF Python tools (MIT), 22 data files (CC-BY 4.0), 7 publication figures, 5 FASTA sequences, molecular dynamics results. GitHub: ThePracticalHow/Quantum-BioAntenna