The effect of anti-S100A11 antibody on cell growth of MPM cell lines

In this study, we focused on the impact of extracellular S100A11 in MPM and explored the therapeutic potential of a S100A11-targeting strategy. We found that the neutralization of extracellular S100A11 using anti-S100A11 antibody significantly inhibit the cell growth of MPM cell lines. We also showed that the secretion of S100A11 was significantly higher in MPM pleural effusions, compared to others, suggesting the possibility for the use of S100A11 as a biomarker. Our results indicate that extracellular S100A11 plays important roles in MPM and may be a therapeutic target in S100A11-secreting MPM. Altered gene expression induced by anti-S100A11 antibody was examined. Two MPM cell lines (H2052, H2452) were used for this experiment.