Homology of the PP1c consensus binding motifs deduced from the AIF sequence in different species.

AIF proteins contain a putative PP1c docking sequence (R/K)x (0,1)V/IxFxx(R/K)x(R/K) which combines the two canonical PP1c docking motifs (R/K)x(0,1)V/IxF and Fxx(R/K)x(R/K) initially characterized in certain Bcl-2 proteins [1], [6].Sequences are shown with a single letter code for amino acids, and residues corresponding to invariable amino acids in the PP1c site are in capital letters.