Single cell sequencing datasets of tibial nerves from diabetic neuropathy (DPN) patients and traumatic limb amputation (TLA) patients.

To understand the cellular diversity and alterations in the pathogenesis of diabetic neuropathy (DPN), weenrolled 4 DPN patients, 3 traumatic limb amputation (TLA) patients at the Department of Orthopedic Surgery of Shanghai Sixth People's Hospital, Shanghai, China. Overall design: Tibial nerves were collected during amputation surgeries in patients suffering from diabetic peripheral neuropathy (DPN) or patients with traumatic limb amputation (TLA). Nerve samples isolated from TLA patients were set as control group. Tibial nerves from donors were rapidly frozen on liquid nitrogen in the operating room and stored until tissue digestion. The sequencing data for 4 DPN samples were named as "DPN_Sample 1-4" and the sequencing data for 3 TLA samples were named as "TLA_Sample 1-3".