To identify possible genomic differences between primary and locally recurrent sarcomas, we performed whole exome sequencing (WES) of amputated (Amp) and matched locally recurrent (LR) tumors from mic

NIAID Data Ecosystem90

EWS-FLI1-induced osteosarcoma model unveiled a crucial role of impaired osteogenic differentiation on osteosarcoma development [ChIP-seq]. Mus musculus

肉瘤分子机制

成骨分化障碍

EWS-FLI1, a multi-functional fusion oncogene, is exclusively detectable in Ewing sarcomas. However, previous studies reported that a subset of osteosarcomas also harbor EWS-ETS family fusion, suggesti

NIAID Data Ecosystem40

The fibroblast epigenome underlies SS18::SSX-mediated transformation in synovial sarcoma

肉瘤发病机制

表观遗传重编程

Synovial sarcoma (SyS) is an aggressive soft-tissue malignancy that is characterized by a pathognomonic t(X;18)(p11.2;q11.2) translocation, which produces the fusion oncogene named SS18::SSX. Despite

NIAID Data Ecosystem30

EWS-FLI1-induced osteosarcoma model unveiled a crucial role of impaired osteogenic differentiation on osteosarcoma development

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