Transcriptome profiling of control and FOSL1 knockdown Rcho-1 trophoblast stem (TS) cells

In hemochorial placentation, trophoblast stem cells differentiate into multiple lineages to aquire specific functions, such as invasive and endocrine phenotype. FOSL1 has been identified as a key regulator for trophoblast differentiation. We used microarray to detail mechanisms underlying FOSL1 signaling pathway in trophoblast differentiation.在血绒毛膜胎盘形成（hemochorial placentation）过程中，滋养层干细胞（trophoblast stem cells）会分化为多种细胞谱系，以获得侵袭性与内分泌表型等特定功能。已有研究证实FOS样抗原1（FOSL1）是调控滋养层分化的关键因子。本研究通过基因芯片（microarray）技术，详细解析了FOSL1信号通路在滋养层分化过程中的潜在调控机制。