mutation during CRISPR/Cas
收藏NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/sra/DRP011896
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资源简介：
the effects of CRISPR/Cas9-induced double-strand DNA breaks on the repair processes of naturally occurring genome-wide mutations is unclear. After gRNA/Cas9 editing, these cells produced 859 mutations, including 67 high-impact variants that severely affected cellular functions under standard culture conditions.In contrast, gRNA/Cas9-edited cells under conditions of S~G2/M arrest and cyclin dependent kinase 1 inhibition showed only 5 mutations.
创建时间：
2024-08-10
