Effects of Pulsatilla Decoction Butanol on glucose metabolism mediated by HIF-1a signal in vaginal epithelial cells stimulated by Candida albicans

On the basis of previous work, this study first made clear that BEPD plays an antagonistic role against the invasion of Candida albicans by activating HIF-1a pathway to improve hypoxia adaptation and regulating glucose metabolism to restore immune function. The results not only revealed the pathogenic chain of "metabolic disorder-immunosuppression" in the process of Candida albicans infection, but also confirmed the application potential of BEPD as a metabolic regulator in anti-fungal infection. More importantly, this study suggests that HIF-1a pathway and glucose metabolism homeostasis regulation can be used as a new direction of antibacterial and antiviral therapy, which provides important theoretical support for developing new anti-infective drugs targeting metabolic reprogramming, and also opens up new ideas for solving clinical fungal drug resistance problems.