Data from: Multi-contrast submillimetric 3-Tesla hippocampal subfield segmentation protocol and dataset

The hippocampus is composed of distinct anatomical subregions that
participate in multiple cognitive processes and are differentially
affected in prevalent neurological and psychiatric conditions. Advances in
high-field MRI allow for the non-invasive identification of hippocampal
substructure. These approaches, however, demand time-consuming manual
segmentation that relies heavily on anatomical expertise. Here, we share
manual labels and associated high-resolution MRI data (MNI-HISUB25;
submillimetric T1- and T2-weighted images, detailed sequence information,
and stereotaxic probabilistic anatomical maps) based on 25 healthy
subjects. Data were acquired on a widely available 3 Tesla MRI system
using a 32 phased-array head coil. The protocol divided the hippocampal
formation into three subregions: subicular complex, merged Cornu Ammonis
1, 2 and 3 (CA1-3) subfields, and CA4-dentate gyrus (CA4-DG). Segmentation
was guided by consistent intensity and morphology characteristics of the
densely myelinated molecular layer together with few geometry-based
boundaries flexible to overall mesiotemporal anatomy, and achieved
excellent intra-/inter-rater reliability (Dice index ≥90/87%). The dataset
can inform neuroimaging assessments of the mesiotemporal lobe and help to
develop segmentation algorithms relevant for basic and clinical
neurosciences.