Smoking, alcohol, dietary folate and adenoma risk by genotype among all subjects.

aOdds ratios (ORs) are from models with genotype coded as log-additive (treated as continuous) and adjusted for age, sex, clinic, exam date, study phase, and race among all study participants. Excludes 21 individuals who characterized their race/ethnic group as "other";bORs for smoking additionally adjusted for alcohol intake (g/d) and dietary folate intake (mcg/day); ORs for alcohol additionally adjusted for smoking pack-years and dietary folate intake (mcg/d); ORs for dietary folate intake, additionally adjusted for alcohol intake (g/d) and smoking pack-years;cORs derived from a common baseline model that included the SNP, smoking, alcohol, dietary folate exposure and interaction terms between genotype and smoking, alcohol, dietary folate exposure levels;dCrude interaction p-value;eWithin gene region, Bonferroni adjusted interaction p-value, based on the number of SNPs within the respective gene region;fPathway wide, Bonferroni adjusted interaction p-value, based on 14 investigated BER gene regions.