Augmented expansion of Treg cells from healthy and autoimmune subjects via adult progenitor cell co-culture.

Here we expand Treg in the presence of Multipotent adult progenitor cells (MAPC(R)) and demonstrate significantly improved expansion when compared to Treg alone. Additionally, MAPC cell expanded Treg have a less exhausted more proliferative phenotype and display a unique gut homing phenotype, supporting the use of MAPC cell co-culture when developing adoptive Treg therapies.