Research data and code for Numerical investigation of the sensitivity of Acousto-optic imaging to absorption

Introduction This repository contains the code and data associated with the research article: Rahghuraman et al., "Numerical investigation of the sensitivity of Acousto-optic imaging to absorption" The code requires the NIRFASTerFF package to run. The NIRFASTerFF package is freely available at https://github.com/milabuob/nirfaster-FF Publication status: Submitted on: 21/07/2026 Under review Files description 1 Jacobians_homog.ipynb This notebook contains code to compute the absorption-sensitivity profiles of AOI using the adjoint model for Homogeneous media: the DC, AC and MD Jacobians are computed and plotted. Generates Figure 2.(a),(b),(c),(d) and (e) 2.1 validation_DC.ipynb, 2.2 validation_AC.ipynb and 2.3 validation_MD.ipynd These notebooks contains code to compute the dOD using both the perturbation and adjoint models, and compares the results to validate the adjoint model in the context of Acousto-Optic Imaging: For DC, AC and MD cases. Generates Figure 3.(a),(b),(c),(d),(e) and (f) 3 create_jacobians.ipynb This notebook contains code to compute and save (in the "Raw" folder) the DC and MD-Jacobians. 4 generate_dOD.ipynb This notebook contains code to generate the difference of data (dOD) arising from an absorption perturbation scanned along the depth using the Jacobian method in the DC and MD case. 5 create_figures.ipynb This notebook contains code to generate the Figures 4.(a)-(c) and 5.(a)-(f) of the article. The saved DC and MD-dOD's are read from the "Processed" folder Data.zip This archive contains the data generated by the simulation. More details is given in readme files in each folders in the archive.