UDEDB

To depict the landscape of molecular changes in the endometrium undergoing cyclic dynamic changes, we developed the Uterine Dynamic Expression Database (UDEDB), a comprehensive resource that integrates published literature, single-cell sequencing data from the Human Endometrial Cell Atlas (HECA), and our experimental bulk RNA sequencing data from both humans and mice. Through literature mining of PubMed and EuropePMC, UDEDB provides detailed descriptions of the 2,020 reported molecules, including PubMed IDs, species, molecular types, experimental verification methods and references to high-throughput sequencing data. To further elucidate the mechanisms driving these expression changes, we conducted literature mining and systematically curated 4,349 transcriptional regulatory entries for both humans and mice across different uterine stages. Additionally, it offers gene expression values and dynamic expression trends across various phases of the human endometrial menstrual cycle, as well as different stages in pseudo-pregnant mouse epithelia.为描绘经历周期性动态变化的子宫内膜的分子变化全貌，我们开发了子宫动态表达数据库（Uterine Dynamic Expression Database, UDEDB）——这是一款整合了已发表文献、人类子宫内膜细胞图谱（Human Endometrial Cell Atlas, HECA）的单细胞测序数据，以及我们获取的人类与小鼠实验批量RNA测序数据的综合性资源。通过对PubMed和欧洲PubMed中心（EuropePMC）开展文献挖掘，UDEDB为2020个已报道的分子提供了详细描述，涵盖PubMed编号、物种、分子类型、实验验证方法以及高通量测序数据的参考文献。为进一步阐明驱动此类表达变化的分子机制，我们开展了文献挖掘工作，并系统整理了人类和小鼠在不同子宫阶段的4349条转录调控条目。此外，该数据库还提供了人类子宫内膜月经周期各阶段以及假孕小鼠上皮细胞不同阶段的基因表达量与动态表达趋势。

搜集汇总

背景与挑战

背景概述

UDEDB（子宫动态表达数据库）是一个精心策划的资源库，专注于描述子宫内膜在月经周期中的复杂分子动态变化。该数据库基于科学文献，利用生物信息学技术和AI辅助系统整理数据，旨在为研究人员和临床医生提供揭示激素调节与子宫内膜相互作用的关键资源。