Data - Koppenwallner et al. - Short pulse epiretinal stimulation allows focal activation of retinal ganglion cells

Patch clamp data associated with Koppenwallner et al. - Short pulse epiretinal stimulation allows focal activation of retinal ganglion cells

Data, as well as simplified load and plot functions. The data is the basis for figures 2-4 in Koppenwallner et al. (10.1109/TNSRE.2025.3529940). Functionality includes loading results from a specified retinal ganglion cell (RGC) and plotting spiking output (e.g., membrane voltage over time) but does not perform threshold searching or other, more complex, analysis.

Context and methodology

Data was created by patch clamp electrophysiology of mouse retinal ganglion cells

Electrical stimulation was applied to test the effect of 10-μs-long biphasic pulses on RGC activation threshold

Technical details

Data can directly be loaded and plotted in Matlab running plotData.m (tested in Matlab R2024b)

Parameters to be specified:

cellID - identifier of each recorded cell, see list on top of plotData.m. Don't forget to add the folder prefix specifiying healthy (wt) and diseased (rd) animals

loc - location of the stimulating electrode during the experiemtn (soma or axon)

dur - pulse duration (10, 25, 50, 250 or 500, in us)

The Data folder is structured into wild-type (wt, healthy animal) and retinal degneration (rd, blind animal) data

If help is needed feel free to reach out to Paul Werginz