Poly(A) RNA sequencing reveals age-related differences in the prefrontal cortex of dogs

The goal of the current study was to explore the transcriptomic differences between young and old dogs frontal cortex, which is a brain region often affected by various forms of age-related dementia in humans. RNA isolates from the frontal cortical brain area of 13 pet dogs, which represented seven different breeds and crossbreds, were analyzed. The poly(A) tail RNA subfraction of the total transcriptome was targeted in the sequencing analysis. Some genes were found to behave more similarly to humans than to rodents, further supporting the applicability of dogs in translational aging research.