Mutations identified in the 3D coding region in the mutant spectrum of the population passaged in the presence of ribavirin P9 R and the parental FMDV population C-S8c1.

aPopulation P9 R is that derived from passaging FMDV C-S8c1 nine times in the presence of 5 mM ribavirin, as detailed in the legend for Figure 1 and in Materials and Methods. C-S8c1 is the parental population used to initiate the passages.bThe mutations observed in the mutant spectrum of P9 R and C-S8c1 are indicated. The total number of nucleotides sequenced, mutation frequency and Shannon entropy are given in Table 2.cAmino acid substitutions deduced from the mutations listed in the second column. A dash line means a synonymous mutation.dThe molecular clones have been numbered to identify linked and repeated mutations.