Comparative metagenomics of gut microbiota in tuberculosis

Tuberculosis patients need to take multiple drugs for several months for effectively clearing the pathogen. Identifying important gut microbiota, that are critical for a healthy immune system, lost in tuberculosis patients at case presentation might be useful as adjunct therapeutics to improve the effectiveness of the existing drugs and may reduce the treatment duration. In this study, our aim is to identify important gut microbiota in tuberculosis patients by comparing their gut microbiome with respect to non tuberculosis and healthy controls recruited from similar geographical locations. We identified a set of important microbiota and fecal metabolic components which has potential as adjunct therapeutics for tuberculosis patients.