Osteoblast signaling

Osteoblasts are specialized, terminally differentiated uninucleated cells responsible for bone formation. Their activity is tightly regulated by external stimuli, originating from e.g. the parathyroid glands, osteocytes, etc. Along with osteoclasts, which are responsible for bone degradation, osteoblasts are key regulators of the shape and volume of bone tissue.

成骨细胞是负责骨骼形成的专业、终末分化的单核细胞。其活性受到外部刺激的严格调控，这些刺激源包括甲状旁腺、破骨细胞等。与负责骨骼降解的破骨细胞相辅相成，成骨细胞是骨骼组织形态和体积的关键调控者。