DNA methylation in hESC derived brain organoids and iPSC derived neurons, astrocytes and neural progenitors

We studied the impact of ZIKA virus infection on DNA methylation in whole organoids, organoid derived astrocytes, neurons neural progeniotors and hESC or iPSC derived astrocytes, neurons, neural progenotor cells Overall design: Examination of differences in DNA methylation upon ZIKV infection in whole organoid samples or specific cell types