Single-cell RNA sequencing of hippocampal microglia in Fetal growth restriction mouse

Microglia exhibit an overactivated phenotype in a variety of FGR animal models. Further studies have shown that the excessive activation of microglia can last from the perinatal period to adolescence. In recent years, breakthroughs in single-cell sequencing technologies have revealed the high heterogeneity of microglia, and previous studies have identified multiple pathological microglial subpopulations in neuropsychiatric disorders. Nevertheless, in the context of FGR-associated cognitive impairment in offspring, the mechanistic contributions of hippocampal microglia, their heterogeneity at single-cell resolution have not been elucidated. Overall design: scRNA-seq of hippocampal microglia in postpartum three week Control and FGR mice