p-Y705,S727 STAT3 dimer binds NOTCH gene

Phosphorylated STAT3 binds to the promoter of the NOTCH gene downstream of NPM1-ALK signaling in ALCL as assessed by chromatin coimmunoprecipitation (ChIP). NPM1-ALK-dependent NOTCH expression contributes to cellular proliferation and abrogation of NOTCH signaling through treatment with either short hairpin RNAs or gamma secretase inhibitors leads to apoptosis (Larose et al, 2021).

磷酸化的STAT3在NPM1-ALK信号通路下游与ALCL中的NOTCH基因启动子结合，这一过程通过染色质共免疫沉淀技术（ChIP）进行检测。依赖NPM1-ALK的NOTCH表达促进了细胞增殖，而通过短发环RNA或γ分泌酶抑制剂处理以阻断NOTCH信号通路则导致细胞凋亡（Larose等，2021年）。