The focal adhesion kinases regulate leptin action and the weight reducing effect of HDAC6 inhibition

NIAID Data Ecosystem2026-05-10 收录

肥胖治疗机制

HDAC6抑制剂

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https://www.ncbi.nlm.nih.gov/sra/SRP656999 数据链接链接失效反馈

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The goal is to assess the impact of HDAC6 inhibition on the hypothalamic transcriptome of mice with diet-induced obesity.

创建时间：

2026-02-28

Difluoromethyl-1,3,4-oxadiazoles Are Selective, Mechanism-Based, and Essentially Irreversible Inhibitors of Histone Deacetylase 6

HDAC6抑制剂

药物机制研究

Histone deacetylase 6 (HDAC6) is an important drug target in oncological and non-oncological diseases. Most available HDAC6 inhibitors (HDAC6i) utilize hydroxamic acids as a zinc-binding group, which

NIAID Data Ecosystem50

Table 1_Transcriptomic elucidation of Dahuang-Huanglian in promoting white adipose browning in high-fat diet-induced obese rats.xlsx

肥胖治疗机制

白色脂肪褐变

ObjectiveDahuang (Rhei Radix et Rhizoma)-Huanglian (Coptidis Rhizoma) (DHHL), has been shown to effectively treat obesity caused by dietary irregularities. Nevertheless, the fundamental process drivin

NIAID Data Ecosystem20

Quinazolin-2,4-dione-Based Hydroxamic Acids as Selective Histone Deacetylase‑6 Inhibitors for Treatment of Non-Small Cell Lung Cancer

HDAC6抑制剂

非小细胞肺癌治疗

We designed and synthesized quinazolin-2,4-dione-based hydroxamic acids to serve as selective competitive inhibitors of histone deacetylase-6 (HDAC6). The most potent and selective compound, 3d (IC50,

Figshare2019-01-22 更新10

Empagliflozin Improves Obesity via Regulating Gut Microbiota-Mediated Tryptophan Metabolism and Intestinal Homeostasis

消化道微生物组

肥胖治疗机制

To explore whether empagliflozin regulates host function through gut microbes to reduce obesity

NIAID Data Ecosystem30

Single nucleus RNA-seq comparison of TYA018 HDAC6 inhibition and Empagliflozin SGLT2 inhibition to treat heart failure with preserved ejection fraction. Single nucleus RNA-seq comparison of TYA018 HDAC6 inhibition and Empagliflozin SGLT2 inhibition to treat heart failure with preserved ejection fraction

心脏衰竭治疗

HDAC6抑制剂

Heart failure with preserved ejection fraction (HFpEF) is a prevalent health condition associated with high morbidity and mortality, but currently, there are few effective therapies. Our previous rese

NIAID Data Ecosystem10

The focal adhesion kinases regulate leptin action and the weight reducing effect of HDAC6 inhibition

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