Expression data from wild type or KLF15 knockout mouse skeletal muscle after immobilization. Expression data from wild type or KLF15 knockout mouse skeletal muscle after immobilization

Evidence suggests that immobilization is a promoting factor of sarcopenia; mechanism how immobilization accelerates the development of sarcopenia is not known. We have recently established a model of immobilization-induced skeletal muscle mass loss in mice. We used microarrays to detail the global programme of gene expression underlying skeletal muscle atrophy in immobilized mice and identified up-regulated or down-regulated genes during this process. Overall design: Gastrocnemius muscle were selected at 3 days after immobilization of wild type or skeletal muscle specific KLF15 knockout mice for RNA extraction and hybridization on Affymetrix microarrays.