Tracking replication enzymology in vivo by genome-wide mapping of ribonucleotide incorporation

Alliance of Genome Resources2026-08-01 收录

DNA复制保真度

核糖核苷酸掺入图谱

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https://www.yeastgenome.org/dataset/GSE62181 数据链接链接失效反馈

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Multiple DNA polymerases are needed to replicate genetic information

The dynamics of DNA methylation fidelity during mouse embryonic stem cell renewal and differentiation

DNA复制保真度

胚胎干细胞分化

Purpose: we aimed to gain a genome-wide view of the dynamics in DNA methylation inheritance and define the factors associated with methylation fidelity. Methods: Using mouse embryonic stem cell (ES-E1

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Effects of mutant dnaN alleles on spontaneous mutagenesis.

分子遗传学突变机制

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Effects of mutant dnaN alleles on spontaneous mutagenesis.

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A Reversible Histone H3 Acetylation Cooperates with Mismatch Repair and Replicative Polymerases in Maintaining Genome Stability

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Mutations are a major driving force of evolution and genetic disease. In eukaryotes, mutations are produced in the chromatin environment, but the impact of chromatin on mutagenesis is poorly understoo

NIAID Data Ecosystem30

Temporal regulation of dUTP biosynthesis limits uracil incorporation during early DNA replication. Saccharomyces cerevisiae

核苷酸代谢调控

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Antimetabolite chemotherapies increase uracil levels in DNA, and thus identification of factors that influence the uracil content in DNA may have implications for understanding uracil-mediated chromos

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Increased and Imbalanced dNTP Pools Symmetrically Promote Both Leading and Lagging Strand Replication Infidelity

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dNTP池失衡突变机制

The fidelity of DNA replication requires an appropriate balance of dNTPs, yet the nascent leading and lagging strands of the nuclear genome are primarily synthesized by replicases that differ in subun

NIAID Data Ecosystem30

Tracking replication enzymology in vivo by genome-wide mapping of ribonucleotide incorporation

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